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Watch out for aneuploidy

William Wells

Genome Biology 2000, 1:spotlight-20000629-01  doi:10.1186/gb-spotlight-20000629-01

The electronic version of this article is the complete one and can be found online at:

Published:29 June 2000

© 2000 BioMed Central Ltd

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In an analysis of both new and old microarray data in the July Nature Genetics, Hughes et al. find that results are frequently skewed by aneuploidy (Nat. Gen. 2000, 25:333-337). Their first clue was an unexpected transcript profile similarity between two unrelated yeast mutants; the cause turned out to be an extra copy of an entire chromosome. Approximately 8% of the yeast mutants examined had chromosome-wide expression biases, even though most of these mutants are not known to have chromosome transmission defects. In five cases a gained chromosome had a close homologue of the deleted gene, and in two cases a growth advantage was demonstrated.


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    Nature genetics