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Methylated but noisy

William Wells

Genome Biology 2000, 1:spotlight-20000518-02  doi:10.1186/gb-spotlight-20000518-02

The electronic version of this article is the complete one and can be found online at:

Published:18 May 2000

© 2000 BioMed Central Ltd

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Interfering with DNA methylation in the plant Arabidopsis, as in animals, disrupts transcriptional gene silencing. But the reverse is not necessarily true. In the 11 May Nature Amedeo et al. describe the first plant or animal gene that, when inhibited, results in disrupted silencing but intact methylation (Nature 2000, 405:203-206). They find the gene, MOM1, by looking for expression from a silenced drug-resistance locus after a random-insertion mutagenesis. The most noticeable homology in MOM1 protein is to the ATPase/helicase region of the SWI2 silencing protein. MOM1 may aid in silencing by acting either downstream or independent of methylation.


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    PubMed Abstract OpenURL

  2. [] webcite

    Nature Genetics