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Double-promoting transcription

William Wells

Genome Biology 2000, 1:spotlight-20000508-02  doi:10.1186/gb-spotlight-20000508-02

The electronic version of this article is the complete one and can be found online at:

Published:8 May 2000

© 2000 BioMed Central Ltd

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Eukaryotic transcription gets started with the binding of the TATA-binding protein (TBP) to the promoter. This basic machinery is not invariant, however; 1993 saw the discovery of the TBP-related TRF1, which directs an ill-defined set of tissue- and gene-specific transcription events. In the May 5 Science Holmes and Tjian find that tandem promoters in tudor, a fly gene, allow for regulation by both TBP and TRF1 proteins (Science 2000, 288:867-870). The proteins direct transcription from distinct start sites, with TRF1 requiring a TC-rich box. Preliminary gene array analysis suggests that about 5% of fly genes may respond to TRF1 induction.


  1. A new factor related to TATA-binding protein has highly restricted expression patterns in Drosophila.

    PubMed Abstract | Publisher Full Text OpenURL

  2. Transcription properties of a cell type-specific TATA-binding protein, TRF.

    PubMed Abstract | Publisher Full Text OpenURL

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