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Molecular mechanisms of spindle function

Claire E Walczak

Author Affiliations

Medical Sciences, Indiana University, Bloomington, IN 47405, USA

Genome Biology 2000, 1:reviews101-reviews101.4  doi:10.1186/gb-2000-1-1-reviews101

Published: 27 April 2000


The key molecules involved in regulating the assembly and function of the mitotic spindle are shared by evolutionarily divergent species. Studies in different model systems are leading to convergent conclusions about the central role of microtubule nucleation and dynamics and of kinesin-related motor proteins in spindle function.