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An overview of the structures of protein-DNA complexes

Nicholas M Luscombe1, Susan E Austin1, Helen M Berman2 and Janet M Thornton13*

Author Affiliations

1 Biomolecular Structure and Modelling Unit, Department of Biochemistry and Molecular Biology, University College, Gower Street, London WC1E 6BT, UK

2 Department of Chemistry, Rutgers State University, Piscataway, New Jersey 08855, USA

3 Department of Crystallography, Birkbeck College, Malet Street, London WC1E 7HX, UK

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Genome Biology 2000, 1:reviews001-reviews001.37  doi:10.1186/gb-2000-1-1-reviews001

Published: 9 June 2000


On the basis of a structural analysis of 240 protein-DNA complexes contained in the Protein Data Bank (PDB), we have classified the DNA-binding proteins involved into eight different structural/functional groups, which are further classified into 54 structural families. Here we present this classification and review the functions, structures and binding interactions of these protein-DNA complexes.